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目的：了解恶性疟原虫对各种常用抗疟药的敏感性，以指导合理应用抗疟药。方法：采用ＷＨＯ标准体外微量法。结果：甲氟喹和奎宁分别测定３６例和３３例，未发现抗性病例。氯喹、氨酚喹和哌喹抗性率分别为８４．６％、８６．１％和３８．０％。有８．３％病例对咯萘啶有抗性，少数病例对青蒿素类药物敏感性下降。结论：云南和海南两省恶性疟原虫对氯喹、氨酚喹和哌喹有高度抗性，但停用氯喹后，恶性疟原虫对氯喹敏感性有所恢复。对哌喹抗性率和抗性程度呈现逐渐上升趋势。对咯萘啶和青蒿素类药物的敏感性在逐渐降低。上述抗疟药抗性之间有一定交叉关系。
Objective: To understand the sensitivity of Plasmodium falciparum to various commonly used antimalarial drugs to guide the rational use of antimalarial drugs. Methods: The WHO standard in vitro micro-method. Results: Mefovir and quinine were detected in 36 cases and 33 cases, no cases of resistance were found. The resistance rates of chloroquine, paracetamol and piperacil were 84.6%, 86.1% and 38.0% respectively. In 8.3% of the cases, pyronaridine was resistant, and in a few cases the sensitivity of artemisinin decreased. Conclusion: Plasmodium falciparum in Yunnan and Hainan provinces are highly resistant to chloroquine, paracetamol and piperaquine. However, the sensitivity of Plasmodium falciparum to chloroquine was restored after chloroquine was stopped. The rate of resistance to piperine and the degree of resistance showed a gradual upward trend. Sensitivities to pyronaridine and artemisinin are gradually decreasing. There is some cross-correlation between the antimalarial resistance mentioned above.