论文部分内容阅读
肌酸尿时多见而又为主要病因的腺嘌呤广泛地应用于临床,但是腺嘌呤过多对人体是有害的。到目前为止,只有应用雄性动物研究腺嘌呤影响的报告。在雄鼠发现喂饲富含腺嘌呤的饲料会引起肾衰竭。由于腺嘌呤对雌性动物的影响的报告还甚少,本实验研究了腺嘌呤处理对不同性别大鼠的影响,并进行了讨论。年轻雄性和雌性大鼠分别给与一种预定浓度的腺嘌呤(6、60及100mg/mL)共8周(3次/周)。结果100mg/mL腺嘌呤处理能引起雄鼠肾衰,50mg/mL能引起肾功能失调。但是,只有100mg/mL才能引起雌鼠肾功能失调,其影响与雄性大鼠有些不同。雄鼠血清睾酮水平及BMD可因腺嘌呤处理而降低,但肾功能失调可有可无。相反,雌鼠尽管有肾功能失调,血清17-β雌二醇水平及BMD可完全不受腺嘌呤处理的影响。如上所述,本研究能说明腺嘌呤对骨代谢的影响是通过性激素合成实现的。腺嘌呤常含于临床药物及日常食物中,过多摄入包括腺嘌呤在内的核酸会影响内分泌功能。
A creatinine more common but as the main cause of adenine widely used in clinical, but excessive adenine is harmful to the human body. So far, only reports of the effects of adenine using males have been studied. In male rats found that feeding adenine-rich feed can cause kidney failure. Because adenine has little effect on female animals, this study investigated the effects of adenine treatment on different sexes in rats and was discussed. Young male and female rats were given a predetermined concentration of adenine (6, 60 and 100 mg / mL) for a total of 8 weeks (3 times / week). Results 100mg / mL adenine treatment can cause male rat renal failure, 50mg / mL can cause renal dysfunction. However, only 100 mg / mL can cause renal dysfunction in females, the effect of which is somewhat different from that of male rats. Male rats with serum testosterone levels and BMD may be reduced due to adenine treatment, but renal dysfunction may be dispensable. In contrast, female rats, despite their renal dysfunction, had no effect on serum 17-beta estradiol levels and BMD from adenine treatment. As mentioned above, this study shows that the effect of adenine on bone metabolism is achieved through sex hormone synthesis. Adenine is often contained in clinical medicine and daily food, excessive intake of nucleic acids, including adenine, will affect the endocrine function.