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目的应用经瞳孔温热疗法(TTT)治疗老年性黄斑变性(AMD)合并脉络膜新生血管(CNV)和高度近视合并CNV,比较治疗后的黄斑平均视敏度(MS)、平均缺损(MD)、视力等变化。方法收集湿性AMD28例32眼和高度近视合并CNV16例20眼。所有患者治疗前后均行眼底、视力、FFA、OCT等检查确诊。应用IRISmedicalOculightSLx激光仪进行治疗。用SPSS10统计分析TTT治疗后3m、6m的视力及中心视野M2程序中MS、MD值。结果治疗1m时,两组治疗有效者分别为25/32眼;16/20眼。治疗3个月时,两组治疗有效者分别为28/32眼;16/20眼。两组间差异无意义(P=0.58;0.36)。治疗6m时,两组治疗有效者分别为28/32眼;12/20眼,两组间差异有显著意义(P=0.02)。AMD合并CNV者TTT治疗前MS值13.70±5.03dB,治疗后3m、6m的MS值分别为16.30±6.2dB,16.90±5.93dB(P=0.088;0.037)。TTT治疗前MD值13.58±4.88dB,TTT治疗后3m、6m的MD值分别为11.27±5.32dB,11.76±4.84dB。(P=0.084;0.172)。高度近视合并CNV者TTT治疗前MS值14.70±4.85dB,TTT治疗后3m、6m的MS值分别为16.62±5.09dB,14.90±4.21dB(P=0.206;0.897)。TTT治疗前MD值14.46±5.21dB,TTT治疗后3m、6m的MD值分别为13.29±4.59dB,15.34±4.38dB(P=0.436;0.562)。结论TTT对CNV有治疗作用,对周围组织存在相对较小的损伤,能保持和提高视功能。6m时疗效AMD组好于高度近视组。
Objective To investigate the clinical effect of pupillary hyperthermia (TTT) on age-related macular degeneration (AMD) combined with choroidal neovascularization (CNV) and high myopia with CNV.MATERIAL MEASUREMENTS Vision changes. Methods 32 eyes of 32 patients with wet AMD and 20 eyes of 16 patients with high myopia and CNV were collected. All patients before and after treatment were fundus, visual acuity, FFA, OCT and other tests confirmed. Applications IRISmedicalOculightSLx laser treatment. With SPSS10 statistical analysis of TTT 3m, 6m visual acuity and central visual field M2 program MS, MD values. Results 1m treatment, the two groups were treated effectively 25/32 eyes; 16/20 eyes. At 3 months, 28/32 eyes and 16/20 eyes were treated in each group. There was no significant difference between the two groups (P = 0.58; 0.36). Treatment 6m, the effective treatment of the two groups were 28/32 eyes; 12/20 eyes, the difference between the two groups was significant (P = 0.02). The MS value of TTT in AMD patients with CNV was 13.70 ± 5.03 dB before treatment, and the MS values at 3 and 6 months after treatment were 16.30 ± 6.2 dB and 16.90 ± 5.93 dB, respectively (P = 0.088; 0.037). The TT before treatment was 13.58 ± 4.88dB, and the MD values at 3m and 6m after TTT were 11.27 ± 5.32dB and 11.76 ± 4.84dB, respectively. (P = 0.084; 0.172). The MS value of TTT in high myopia patients with CNV was 14.70 ± 4.85dB before and after TTT treatment. The MS values at 3m and 6m after TTT were 16.62 ± 5.09dB and 14.90 ± 4.21dB, respectively (P = 0.206; 0.897). The MD value of TTT before treatment was 14.46 ± 5.21dB, and the MD values of 3m and 6m after TTT treatment were 13.29 ± 4.59dB and 15.34 ± 4.38dB respectively (P = 0.436; 0.562). Conclusion TTT has a therapeutic effect on CNV, and has relatively small damage to the surrounding tissues, which can maintain and improve visual function. 6m efficacy AMD group was better than high myopia group.