论文部分内容阅读
目的 测定川芎哚 (川芎III号碱 ,perlolyrine)的药动学参数。方法 以氘标川芎哚为内标准及GC MS的SIM(选择性离子监测 )为检测手段 ,定量测定大鼠体内川芎哚的含量及其药代动力学参数。结果 川芎哚在大鼠体内呈二室模型分布 ,其药代动力学参数为 :T1/ 2α=0 34h ,T1/ 2 β=4 5 9h ,T1/ 2 (Ka) =0 12h ,Tmax=0 36h ,Cmax=18 86μg·L-1,K12 =0 87h-1,K2 1=0 40h-1,K10 =0 31h-1,VB=10 7 86L·kg-1,AUC =99 6 8μg·h·L-1。结论 本法灵敏度高、特异性强和准确性好 ,为临床应用提供了科学依据。
Objective To determine the pharmacokinetic parameters of Chuanxiong Rhodamine III (perlolyrine). Methods The deuterium standard chuanxiongluo as internal standard and GC MS SIM (selective ion monitoring) as a means of detection, quantitative determination of rat body of Chuanxiongodole content and pharmacokinetic parameters. Results Chuanxiongodole was distributed in a two-compartment model in rats. The pharmacokinetic parameters were T1 / 2α = 0 34h, T1 / 2 β = 459h, T1 / 2 (Ka) = 0 12h, Tmax = 0 36h Cmax = 18 86μg · L-1 K12 = 0 87h-1 K2 1 = 0 40h-1 K10 = 0 31h-1 VB = 10 7 86L · kg -1 AUC = 99 6 8μg · h · L-1. Conclusion This method has high sensitivity, specificity and accuracy, and provides a scientific basis for clinical application.