肺气肿和肺间质纤维化是两种临床常见疾病,且常常同时或相继发生,形成肺间质纤维化合并肺气肿(combined pulmonary fibrosis and emphysema,CPFE)。但此两种疾病的发病机制尚待研究。目前的研究结果表明,CPFE的发生与体内外环境有关,外部环境包括吸烟、污染等,内部患者包括敏感体质等[1-2]。同时,体内细胞因子水平的变化也与CPFE的发生发展密切关 Emphysema and interstitial fibrosis are two common clinical diseases and often occur simultaneously or sequentially to form combined pulmonary fibrosis and emphysema (CPFE). However, the pathogenesis of these two diseases remains to be studied. The current results show that the occurrence of CPFE and in vivo environment, the external environment, including smoking, pollution, internal patients, including the sensitive constitution [1-2]. At the same time, changes in the level of cytokines in vivo are also closely related with the occurrence and development of CPFE