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用[~3H]-藏花素大鼠灌胃,血药半对数浓度-时间曲线用残数法处理,符合线性开放二室模型。中心室药浓度时间方程为:C=-2.7642e~(-0.5330t)+0.5328e~(-0.2592t)+2.1813e~(-0.0085t),主要动力学参数:t(1/2)ka=1.30hr,t(1/2)α=2.675r,t(1/2)β=81.53hr,t_(max)=4.54hr,v_1=630.81ml,TBCL=5.36ml/hr。除睾丸外各脏器放射性浓度高峰均出现在给药后 4～6 hr,与血浆中t_(max)一致。给药后96h各脏器中仍残留有一定量的放射性。大鼠灌胃后放射性主要由粪与尿中排出,给药96hr后粪及尿中分别排出全部放射性的68.22％和17.29％。
With [~ 3H] - Crocin fed rats, the blood half-logarithmic concentration-time curve by residual method, in line with the linear open two-compartment model. The central compartment drug concentration time equation was: C = -2.7642e ~ (-0.5330t) + 0.5328e ~ (-0.2592t) + 2.1813e ~ (-0.0085t), the main kinetic parameters were: t (1/2) ka = 1.30 hr, t (1/2) α = 2.675 r, t (1/2) β = 81.53 hr, t max = 4.54 hr, v_1 = 630.81 ml, TBCL = 5.36 ml / hr. Except for the testis, the peak of radioactive concentration in each organ appeared after 4 ~ 6 hr after administration, which was consistent with t max in plasma. 96h after administration of each organ remains a certain amount of radioactivity. Radioactivity in rats was mainly excreted by excrement and urine after intragastric administration, and 68.22% and 17.29% of the total radioactivity were excreted respectively in feces and urine after administration for 96 hours.