1901年Frohlich氏报告一14岁之男孩,伴有头痛,呕吐,视力减退,检查时发现体小,肥胖,乳房膨大,睾丸变小,无腋毛。经手术证实为颅咽管瘤。早在1840年Mohr,1900年Babinski各报告过一例因垂体肿瘤而惹起之肥胖与性功能低下,但后人仍称此病为Frohlich氏综合病征。至1954年止在世界文献中可找到60例经病理证实之视丘下部病变。国内自1952年以来共报导16例,近来对本病的发生机制多倾向视丘下部损伤。本文就我科剖检之几种常见原因所致之视丘下部损伤与3例临床诊断之Frohlich氏综合病症,对视丘下部损伤之病因与表现加以讨论。 1901 Frohlich’s report of a 14-year-old boy with headache, vomiting, vision loss, examination found that small, obese, breast enlargement, testis smaller, no armpit hair. The operation was confirmed as craniopharyngioma. As early as 1840 Mohr, Babinski in 1900 each reported a case of obesity due to pituitary tumors and sexual dysfunction, but the posterity still said the disease is Frohlich’s syndrome. Until 1954 in the world literature can be found in 60 cases of pathologically confirmed hypothalamus lesions. A total of 16 cases have been reported in China since 1952, and the pathogenesis of this disease has tended to be lower in the hypothalamus recently. In this paper, several common causes of hypothalamic injury and 3 cases of Frohlich’s syndrome diagnosed by our department were analyzed, and the etiology and manifestation of the lower part of the hypothalamus were discussed.