早孕期使用男性激素或合成孕激索能使女性胚胎男性化.胚胎在子宫内接受男性激素,并未认为对将来的性别有损害;惟缺乏足以证实的长期随访病例.Dewhurst和Gordon(1984)曾报告1例女孩由于其母在妊娠期应用睾丸酮,出生时外生殖器有严重男性化畸形.婴儿出生时认为是男性,4岁 Male embryos were masculine using either male hormones or synthetic progenitor cords in early pregnancy. Embryos receiving male hormones in the uterus were not considered to have any future gender impairments but lack sufficient evidence of long-term follow-up. Dewhurst and Gordon (1984) One girl who reported having severe male deformities in her external genitalia at birth due to her mother’s application of testosterone during pregnancy was considered as a male at the age of 4 years