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本文试探讨血浆内皮素浓度与高血压病分期及年龄的关系。 对象和方法 一、病例:本院1994年1月～1995年12月住院病人,符合WHO高血压诊断标准及1977年我国修订的高血压临床分期标准共92例,均排除继发性高血压、高血压病合并糖尿病、冠心病、肺心病、周围血管病者,符合高血压病Ⅱ期36例,Ⅲ期37例,共73例。其中,男性38例,女性35例,年龄39～92岁,平均62岁。 二、对照组:正常对照组选取无明显心、肺、脑、肾疾病志愿者35人,年龄36～62岁,平均52岁。 三、内皮素RIA:晨8时,卧位,抽血3ml,EDTA-Na_2抗凝,迅速分离血浆,-70℃低温保存。试剂盒由北京东亚免疫技术研究所提供。 四、统计处理:结果以均数±标准差表示。高血压Ⅱ期、Ⅲ期以及年龄分层分别作t检验及方差分析,P<0.05为显著性差异。
This paper attempts to explore the plasma endothelin concentration and hypertension stage and the relationship between age. Subjects and methods A case: hospital from January 1994 to December 1995 inpatients, in line with the WHO diagnostic criteria for hypertension and in 1977 revised the clinical criteria of hypertension in a total of 92 cases were excluded secondary hypertension, Hypertension with diabetes, coronary heart disease, pulmonary heart disease, peripheral vascular disease, in line with hypertension in 36 cases of stage Ⅱ, 37 cases of stage Ⅲ, a total of 73 cases. Among them, 38 males and 35 females, aged 39 to 92 years, an average of 62 years old. Second, the control group: normal control group selected no obvious heart, lung, brain, kidney disease volunteers 35 people, aged 36 to 62 years, mean 52 years. Third, endothelin RIA: 8 am, lying position, blood 3ml, EDTA-Na 2 anticoagulant, rapid separation of plasma, -70 ℃ cryopreservation. Kit from Beijing East Asia Institute of Immunization Technology provided. Fourth, the statistical processing: The results are mean ± standard deviation. Hypertension Ⅱ, Ⅲ, and age stratification were t test and analysis of variance, P <0.05 for significant differences.