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作者研究彭亨丝虫感染金色仓鼠所致淋巴系统和主要脏器的病理变化,在于确定彭亨丝虫-金色仓鼠模型是否适于研究人体丝虫病的病理学和发病机理。 16只雄性金色仓鼠经腹股沟皮下注射95～150条彭亨丝虫感染期幼虫,39～195天后杀死,观察其病理变化,并以10只正常金色仓鼠作对照。组织用10％中性福尔马林固定,包埋后切片,苏木素-伊红染色。淋巴管病变:可见淋巴管扩张和肉芽肿性淋巴管炎。扩张的淋巴管有的内皮细胞肥
The authors investigated the pathological changes in the lymphatic system and major organs caused by the golden hamster infected with Paenibacillary filariasis in order to determine whether the Penaeid Worm - golden hamster model is suitable for studying the pathology and pathogenesis of human filariasis. Sixteen male golden hamsters were subcutaneously injected with 95-150 Paenibacillus filariasis larvae in the groin, and killed after 39-195 days. The pathological changes were observed and 10 normal golden hamsters were used as controls. Tissues were fixed with 10% neutral formalin, embedded and sectioned, stained with hematoxylin-eosin. Lymphatic vessel disease: lymphangiectasia and granulomatous lymphangitis can be seen. Some of the expanded lymphatic endothelial cell fat