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目的:通过对比的方法,评价醋酸奥曲肽注射液(胃药质子泵抑制剂)和垂体后叶加压素注射液在治疗肝硬化上消化道出血的疗效和安全性。方法:将140例肝硬化上消化道出血患者随机分成2组。实验组采用醋酸奥曲肽注射液治疗70例,对照组采用垂体后叶加压素注射液治疗70例。经过一周的治疗疗程,观察疗效。通过两独立样本t检验的统计学方法,对两组的疗效进行统计学分析。结果:在140例患者中,醋酸奥曲肽注射液治疗组治愈率94.21%,垂体后叶加压素注射液治疗组的治愈率为89.23%。经两独立样本t检验两两比较,醋酸奥曲肽注射液治疗组的治愈率均高于单独用垂体后叶加压素注射液组,P值为0.012(小于0.05)。在两组治疗过程中,患者均未出现严重不良反应,一周后,均对两组患者的大便常规进行隐血试验检测,发现醋酸奥曲肽注射液治疗组大便隐血试验阳性率明显少于垂体后叶加压素注射液治疗组,两组差异有统计学意义P值为0.017。结论:醋酸奥曲肽注射液治疗肝硬化上消化道出血的效果明显好于单独使用垂体后叶加压素注射液的治愈率。同时,在采取两种不同治疗方法的治疗过程中,均无出现严重的不良反应情况发生。
OBJECTIVE: To evaluate the efficacy and safety of octreotide acetate injection (gastric proton pump inhibitor) and pituitary vasopressin injection in the treatment of upper gastrointestinal bleeding due to cirrhosis by contrast method. Methods: 140 patients with cirrhosis and upper gastrointestinal bleeding were randomly divided into two groups. In the experimental group, 70 cases were treated with octreotide acetate injection and 70 cases in the control group with pituitary vasopressin injection. After a week of treatment, observe the effect. Through two independent samples t test statistical methods, the efficacy of the two groups were statistically analyzed. Results: In 140 patients, the cure rate of octreotide acetate injection group was 94.21%, and the cure rate of pituitary vasopressin injection group was 89.23%. The curative rate of octreotide acetate injection group was higher than that of pituitrin alone group with P value of 0.012 (less than 0.05). In the two groups of treatment, the patients did not appear serious adverse reactions, a week later, both groups of patients stool routine occult blood test found that octreotide acetate injection group stool occult blood test was significantly less positive than the posterior pituitary plus Hypertension injection treatment group, the difference between the two groups was statistically significant P value of 0.017. Conclusion: The effect of octreotide acetate injection for the treatment of upper gastrointestinal bleeding in cirrhosis is better than that of vasopressin injection alone. At the same time, there were no serious adverse reactions in the treatment of two different treatment methods.