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目的探讨125I粒子组织间永久植入在腹膜后肉瘤切除术中的应用和疗效。方法回顾性分析了2003年5月—2006年12月7例腹膜后肉瘤切除联合术中在瘤床、肿瘤残存灶内植入125I粒子,每颗粒子活度0.5~0.6 mC i,共植入125I粒子259颗,平均37颗。结果7例患者均顺利完成手术,术后未发生出血、感染、胃肠道穿孔、大血管穿孔、粒子移位等并发症。随访4~25个月,7例均存活。结论腹膜后肉瘤切除联合术中125I粒子组织间永久植入治疗,使手术、放疗同步进行,可明显提高疗效,安全、易操作,是肿瘤综合治疗的有效手段之一。
Objective To investigate the application and efficacy of permanent implantation of 125I seeds in resection of retroperitoneal sarcoma. Methods Retrospective analysis of 7 cases of resectable retroperitoneal sarcoma between May 2003 and December 2006 retrospectively performed implantation of 125I particles in the tumor bed and tumor remnant foci with an activity of 0.5-0.6 mCi per particle. 125I particles 259, an average of 37. Results All the 7 patients were successfully performed the operation without postoperative complications of hemorrhage, infection, gastrointestinal perforation, perforation of large blood vessels and particle displacement. All cases were followed up for 4 ~ 25 months. All of them survived. Conclusions Resection of retroperitoneal sarcoma combined with intraoperative 125I permanent interstitial implantation, the operation, radiotherapy simultaneously, can significantly improve the efficacy, safety, easy to operate, is one of the effective means of comprehensive treatment of cancer.