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目的观察体部伽玛刀联合射频热疗治疗非小细胞肺癌的疗效观察。方法选取医院收治的由于年龄过大未进行手术或患者及家属拒绝手术的非小细胞肺癌(NSCLC)患者21例,均初次接受化疗,应用体部伽玛刀联合射频热疗进行治疗,观察患者近期疗效及放射不良反应。结果 21例患者中CR 4例(19.0%),PR 15例(71.4%),NC 2例(9.5%)。联合治疗总有效率为90.5%。白细胞下降13例(61.9%),经G-CSF皮下注射营养支持治疗后恢复正常,不影响继续治疗;治疗1周后,近50%患者表现乏力、食欲下降等,未特殊处理,治疗后逐渐缓解;放射性肺损伤(1~2度)2例(9.5%),放射性食管损伤(1~2度)4例(19.0%),经对症处理后缓解;胃肠道反应11例(52.4%),但经止吐、镇静及激素等药物处理症状减轻,均可顺利完成治疗;无放射性肺炎及放射性食管出血、穿孔等严重并发症。结论体部伽玛刀联合射频热疗治疗非小细胞肺癌近期疗效好,不良反应轻可耐受,二者相互补充、相互协作,能显著增强治疗效果,提高肺癌患者生存率,改善生活质量,值得临床广泛推广。
Objective To observe the curative effect of body gamma knife radiofrequency thermotherapy on non-small cell lung cancer. Methods Twenty-one patients with non-small cell lung cancer (NSCLC) who were surgically treated due to over-age or were refused surgery were enrolled in this study. All patients were initially treated with radiotherapy, Recent effects and adverse reactions. Results Among the 21 patients, 4 were CR (19.0%), PR 15 (71.4%) and NC 2 (9.5%). The total effective rate of combination therapy was 90.5%. Thirteen cases (61.9%) of leukopenia were returned to normal after subcutaneous injection of G-CSF, which did not affect the continuation of treatment. After one week of treatment, nearly 50% of the patients showed weakness and decreased appetite, without special treatment and gradually after treatment 4 cases (19.0%) of radiation-induced esophageal injury (1-2 degrees) were relieved after symptomatic treatment; 11 cases (52.4%) of gastrointestinal reactions were relieved; , But by antiemetic, sedative and hormone treatment and other symptoms relieve, can successfully complete the treatment; no radiation pneumonitis and radioactive esophageal bleeding, perforation and other serious complications. Conclusion Gamma Knife combined with radiofrequency thermotherapy for non-small cell lung cancer has good curative effect in the near future and mild side effects. The two are complementary and cooperate with each other, which can significantly enhance the therapeutic effect, improve the survival rate of lung cancer patients, improve the quality of life, Worth widespread clinical.