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①目的研究润肠通便口服液（口服液）对实验性便秘及肠道平滑肌的作用。②方法采用燥结型及实热型两种便秘模型及正常小鼠，观察口服液的导泻作用。利用离体豚鼠回肠标本及在体小鼠，观察口服液对肠道平滑肌功能的影响。③结果口服液（６．０ｇ／ｋｇ体重）对两种便秘模型及正常小鼠均有导泻作用，尤其对失水造成的燥结型便秘，可明显增加排便总量及粒数，并可软化粪便，缩短排便时间。口服液能增加肠道平滑肌的收缩力，使在２７℃低温条件下处于抑制状态的离体豚鼠回肠平滑肌肌张力明显提高。在整体实验中，口服液可提高小鼠肠内炭末推进百分率，使小肠推进性运动增强，加速肠内容物的排泄。④结论润肠通便口服液能提高离体肠道平滑肌的兴奋性，促进在体小肠推进性运动，对多种便秘模型有导泻作用
Objective To study the effect of Runchang Tongbian oral liquid (oral liquid) on experimental constipation and intestinal smooth muscle. Methods The constipation-type and real-heat-type constipation models and normal mice were used to observe the effect of oral liquid on catharsis. The effects of oral solution on the function of intestinal smooth muscle were observed by using isolated guinea pig ileum samples and in vivo mice. ③ Results Oral solution (6.0g / kg body weight) had cathartic effect on both constipation models and normal mice. Especially for dry constipation caused by dehydration, the total amount of constipation and the number of particles could be significantly increased Soften the stool, shorten the defecation time. Oral fluid can increase the contractility of intestinal smooth muscle, so that under the conditions of low temperature 27 ℃ inhibition of isolated guinea pig ileum smooth muscle significantly increased muscle tone. In the overall experiment, the oral liquid can improve the percentage of intestinal propulsion of mice in the intestine, so that the propulsive movement of the small intestine is enhanced and the excretion of intestinal contents is accelerated. ④ Conclusion Runchang Tongmai oral liquid can improve the excitability of isolated intestinal smooth muscle and promote propulsive movement in the small intestine, a variety of constipation model has cathartic effect