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目的：研究亚硒酸钠对荷瘤机体的免疫调节作用。方法：实验分别测定了亚硒酸钠+肿瘤组（Ⅰ）、肿瘤对照组（Ⅱ）和正常对照组（Ⅲ）动物的脾淋巴细胞转化率、ANAE+淋巴细胞百分率和免疫器官指数，并在光镜下对脾脏和胸腺的形态学变化作了观察。结果：亚硒酸钠可促进荷瘤机体的T淋巴细胞功能使脾淋巴细胞转化率和ANAE+淋巴细胞百分率增高；促进免疫器官中淋巴组织增殖，使胸腺和脾脏指数远高于二个对照组；其免疫器官的形态学损伤亦较轻。结论：亚硒酸钠可逆转因肿瘤生长而造成的免疫机能低下状态。
Objective: To study the immune regulation effect of sodium selenite on tumor-bearing body. Methods: The spleen lymphocyte transformation rate, percentage of ANAE + lymphocytes and immune organ index in selenite + tumor group (Ⅰ), tumor control group (Ⅱ) and normal control group (Ⅲ) Microscopic observation of the morphological changes of the spleen and thymus. Results: Sodium selenite could promote the function of T lymphocytes in tumor-bearing cells and increase the conversion rate of splenic lymphocytes and the percentage of ANAE + lymphocytes; promote the proliferation of lymphoid tissues in immune organs so that the indices of thymus and spleen were much higher than those of two control groups; The morphological damage of immune organs is also lighter. Conclusion: Sodium selenite reverses the immunocompromised condition caused by tumor growth.