目的研究辛伐他汀在体外对低密度脂蛋白氧化修饰的影响。方法以低密度脂蛋白氧化修饰为模型,以硫代巴比妥酸反应物质(TBARS)生成量及相对电泳迁移率(REM)为指标,研究了辛伐他汀对铜离子(Cu2+)诱导低密度脂蛋白氧化修饰的抑制作用。结果随辛伐他汀浓度从1~10μmol/L的增加,TBARS值分别减少67.3%,73.9%,81.9%,REM值减少48.3%,55.2%,58.6%,呈浓度及时间依赖关系。其中10μmol/L辛伐他汀可几乎完全抑制低密度脂蛋白氧化。结论辛伐他汀在体外能明显抑制Cu2+诱导的低密度脂蛋白氧化修饰。 Objective To study the effect of simvastatin on the oxidative modification of low density lipoprotein in vitro. Methods Oxidative modification of low density lipoprotein (LDL) was used as a model to study the effects of simvastatin on Cu2 + -induced low density Inhibition of lipoprotein oxidative modification. Results As the concentration of simvastatin increased from 1 to 10 μmol / L, the values ​​of TBARS decreased by 67.3%, 73.9% and 81.9%, respectively, and the values ​​of REM decreased by 48.3%, 55.2% and 58.6% in a concentration and time dependent manner. Among them, 10μmol / L simvastatin almost completely suppressed the LDL oxidation. Conclusion Simvastatin can significantly inhibit the oxidative modification of low density lipoprotein induced by Cu2 + in vitro.