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目的探讨鼻及咽部原发性非霍奇金淋巴瘤(NHL)的临床特点、免疫表型及其与 EB病毒感染的关系。方法对158例鼻及咽部原发性 NHL 进行了 HE 和免疫组织化学 SP 法(CD3、CD20、CD56、CD57)检查,按 WHO 2001年《造血和淋巴组织肿瘤的病理学和遗传学》标准进行分类;并对其中99例进行了 EBER-1原位杂交的检测。结果 158例鼻及咽部原发性 NHL 中,原发于鼻腔84例(53.2%),扁桃体39例(24.7%),咽部35例(22.1%)。结外鼻型 NK/T 细胞淋巴瘤101例(63.9%)、非特异性外周 T 细胞淋巴瘤23例(14.6%),B 细胞淋巴瘤34例(21.5%)。99例 EBER-1原位杂交结果显示阳性率:结外鼻型 NK/T 细胞淋巴瘤为98.6%(70/71),而非特异性外周 T 细胞淋巴瘤为66.7%(8/12),B 细胞淋巴瘤为43.8%(7/16)。结论鼻及咽部 NHL 中结外鼻型 NK/T 细胞淋巴瘤最为多见,与 EB 病毒密切相关,其病理诊断需结合其免疫表型特征及肿瘤部位。
Objective To investigate the clinical features, immunophenotype and its relationship with Epstein-Barr virus (EBV) infection in nasal and pharyngeal primary non-Hodgkin’s lymphoma (NHL). Methods 158 cases of nasal and pharyngeal primary NHL were examined by HE and immunohistochemical SP method (CD3, CD20, CD56, CD57), according to the WHO 2001 “pathology and genetics of hematopoietic and lymphoid tumors” standard 99 cases were examined by EBER-1 in situ hybridization. Results Of the 158 cases of nasal and pharyngeal primary NHL, 84 (53.2%) were found in nasal cavity, 39 (24.7%) in tonsil and 35 (22.1%) in pharynx. Extranodal nasal NK / T cell lymphoma in 101 cases (63.9%), nonspecific peripheral T cell lymphoma in 23 cases (14.6%), B cell lymphoma in 34 cases (21.5%). The positive results of 99 EBR-1 in situ hybridization showed that the extranodal nasal type NK / T cell lymphoma was 98.6% (70/71), while the non-specific peripheral T cell lymphoma was 66.7% (8/12), B Cell lymphoma was 43.8% (7/16). Conclusions The extranodal nasal type NK / T cell lymphoma in nasal and pharyngeal NHL is the most common and closely related to Epstein-Barr virus. The pathological diagnosis should be based on its immunophenotypic characteristics and tumor site.