目的　探讨血浆神经肽Y(NPY)含量变化在原发高血压合并心功能不全中的临床意义。方法　采用放射免疫分析法。结果　原发性高血压并发心功能不全患者血浆NPY含量较原发性高血压无心功能不全组显著升高 (P <0 0 1) ;且随着心功能不全程度的加重 ,血浆NPY水平明显升高 (P <0 0 5 ) ,两者呈正相关 (r =0 485 ,P <0 0 5 )。结论　血浆NPY含量变化在高血压并发心功能不全中可能起着一定的作用 Objective To investigate the clinical significance of plasma neuropeptide Y (NPY) content changes in patients with essential hypertension complicated with cardiac insufficiency. Methods Radioimmunoassay was used. Results Plasma NPY levels in patients with essential hypertension complicated with cardiac insufficiency were significantly higher than those without essential hypertension (P <0.01). With the severity of cardiac insufficiency, plasma NPY levels increased significantly (P <0 05), the two were positively correlated (r = 0 485, P <0 05). Conclusion Plasma NPY levels may play a role in the progression of hypertension complicated with cardiac insufficiency