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以鲤细菌出血性败血病致病菌强毒力菌株对诺氟沙星 (Norfloxacin)等 7种抑菌药物进行体外敏感性测定 ,其中诺氟沙星高度敏感 ,最小抑菌浓度 <0 2 μg/mL。体内抗菌药效试验结果表明 ,每kg鱼体重注射 1mg诺氟沙星和口服 1 0mg/d诺氟沙星均能有效杀灭致病菌 ,提高感染鱼成活率。诺氟沙星的药动学研究结果表明 ,混饲给药后 0 75h至 2 4h ,血药浓度在 0 2 μg/mL以上。据此确定给药方案 :口服给药剂量为 1 0mg/(kg·d) ,连续给药 5次 ,在生产中应用效果良好。诺氟沙星对鲤急性口灌毒性实验结果LD50>1 0 0 0mg/kg ( 96h) ,肌肉残毒测定结果证明 ,停药 1 44h即无诺氟沙星检出 ,该药安全范围大 ,残余期短。
Seven strains of bacteriostasis drugs such as Norfloxacin were tested in vitro in the virulent virulent strains of carp bacterial hemorrhagic septicemia. Norfloxacin was highly sensitive and the minimum inhibitory concentration was <0 2 μg / mL. In vivo antibacterial efficacy test results show that, per kg body weight injection of 1mg norfloxacin and oral norfloxacin 10mg / d can effectively kill pathogens and improve the survival rate of infected fish. Pharmacokinetic studies of norfloxacin showed that the drug concentration was 0 2 μg / mL at 0 75 h to 2 4 h after mixed feeding. According to this to determine the dosing regimen: oral dose of 10mg / (kg · d), continuous administration of 5 times, the application of good results in the production. Norfloxacin on the carp acute oral toxicity test results LD50> 1 0 0mg / kg (96h), Muscle remnant determination results show that no withdrawal of 444h norfloxacin detected, the drug safety range, residual Short period.