细胞因子作为主动的或辅助性抗肿瘤剂已被证明。特别是单独给予IL-2及IFN-α时,更进一步证明它们的抗肿瘤作用,但是高剂量的IL-2有很大的副作用,IFN 对弱免疫原性肿瘤作用甚微。因此,本文应用牛痘病毒结肠癌细胞溶解物(VCO)增强肿瘤免疫原性,以达到提高IL-2和INF 在小鼠肝转移模型治疗中更好的协同作用,并与VCO、IL-2、IFN-α的单独或二者联合治 Cytokines have been demonstrated as active or adjuvant anti-neoplastic agents. In particular, when IL-2 and IFN-α were administered alone, their anti-tumor effects were further demonstrated, but high doses of IL-2 had a large number of side effects, and IFN had little effect on weakly immunogenic tumors. Therefore, the use of vaccinia virus colon cancer cell lysate (VCO) to enhance tumor immunogenicity in order to achieve better synergy between IL-2 and INF in the treatment of mouse liver metastases model, and with VCO, IL-2, IFN-α alone or in combination