子宫内膜异位症(EMs)是育龄妇女常见病,病因至今不明,近年研究表明该病发生与血管形成密切相关。血管内皮生长因子(VEGF)是最关键的血管形成因子,可以促进异位病灶的血管形成。抑制血管形成成为近年来治疗EMs的研究热点。α干扰素(IFNα)具有抗血管形成的活性,对利用IFNα对VEGF的抑制作用的机制治疗EMs的可行性进行综述。 Endometriosis (EMs) is a common disease of women of childbearing age, etiology has so far been unknown, recent studies have shown that the occurrence of the disease is closely related to the formation of blood vessels. Vascular endothelial growth factor (VEGF) is the most critical angiogenic factor that promotes angiogenesis in ectopic lesions. Inhibiting angiogenesis has become a hot research topic in recent years. Alpha interferon (IFNα) has anti-angiogenic activity and reviews the feasibility of treating EMs by the mechanism of IFNα inhibition of VEGF.