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动脉粥样硬化过程中,氧化型低密度脂蛋白(ox-LDL)、血管紧张素-Ⅱ(Ang-Ⅱ)、蛋白激酶C(PKC)及各种细胞因子和血流动力学改变都可促进转化生长因子-β(TGF-β)基因表达。而TGF-β可以调节肾脏细胞增殖与分化,干扰细胞外基质的代谢过程,在肾小球硬化和间质纤维化过程中发挥重要作用。
Oxidized low density lipoprotein (ox-LDL), angiotensin-Ⅱ (Ang-Ⅱ), protein kinase C (PKC) and various cytokines and hemodynamic changes can be promoted during atherosclerosis Transforming growth factor-β (TGF-β) gene expression. TGF-β can regulate the proliferation and differentiation of renal cells, interfere with the metabolism of extracellular matrix and play an important role in glomerulosclerosis and interstitial fibrosis.