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目的:比较~(131)I与手术治疗青少年Graves病的疗效,寻找一种安全、有效的治疗青少年Graves病的方法。方法:回顾分析98例药物治疗后复发的青少年Graves病患者,~(131)I治疗41例,手术治疗57例,比较两种方法的疗效及安全性。结果:两组有效率比较,差异无统计学意义(P>0.05),~(131)I组甲减发生率明显高于手术组(P<0.01),而两组复发率差异无统计学意义(P>0.05);两种方法治疗突眼均有效,差异无统计学意义(P>0.05),但手术组突眼加重比率要显著高于~(131)I组(P<0.01)。结论:手术和~(131)I均是治疗青少年Graves病的安全有效方法,~(131)I的剂量要个体化,尽量减少甲减的发生率。
Objective: To compare the efficacy of ~ (131) I with surgical treatment of Graves ’disease in adolescents, and to find a safe and effective method to treat Graves’ disease in adolescents. Methods: A retrospective analysis of 98 patients with recurrent juvenile Graves disease after drug treatment, ~ (131) I treatment in 41 cases, 57 cases of surgical treatment, the efficacy and safety of the two methods were compared. Results: There was no significant difference in the effective rate between the two groups (P> 0.05). The incidence of hypothyroidism in ~ (131) I group was significantly higher than that in the operation group (P <0.01), but there was no significant difference between the two groups (P> 0.05). Both methods were effective in treating exophthalmos, with no significant difference (P> 0.05). However, the rate of exacerbation in the operation group was significantly higher than that in the 131I group (P <0.01). CONCLUSION: Both operation and 131I are safe and effective in the treatment of Graves’ disease in adolescents. The dosage of 131I should be individualized to minimize the incidence of hypothyroidism.