1975年瑞典研究人员首先报道β阻滞剂治疗心衰有效。有人以充血性心肌病患者为对象,进行二项试验。 一项试验中,10例心衰得到控制的患者静脉注射25mg醋丁酰心安,观察即时血流动力学效应。用药后,心率减慢8％(NS),左室喷血分数减小8％(NS),左室搏功指数减小13％(NS),心脏指数减小10％(NS), In 1975, Swedish researchers first reported that beta blockers were effective in treating heart failure. Some people with congestive cardiomyopathy as the object, two tests. In one trial, 10 patients with congestive heart failure received intravenous injection of 25 mg of butyrylbupate and observed for immediate hemodynamic effects. After treatment, the heart rate was reduced by 8% (NS), the left ventricular ejection fraction was reduced by 8% (NS), the left ventricular stroke index was reduced by 13% (NS), and the cardiac index was reduced by 10% (NS)