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目的为临床及时发现、诊断、治疗利福平所致急性肾功能衰竭提供参考。方法对我院利福平致急性肾功能衰竭1例及国内已经报道的临床资料进行综合分析。结果综合我院1例利福平致急性肾功能衰竭及文献报道共44例患者的一般资料、给药方法、发生时间、处理及结果,其中32例既往有使用利福平史,在服药后15分钟至50天发病,积极治疗后可缓解。结论在使用利福平的过程中应密切监测肾功能,及时发现利福平所致的急性肾功能衰竭。
Objective To provide a reference for the clinical discovery, diagnosis and treatment of acute renal failure caused by rifampicin. Methods One case of acute renal failure caused by rifampicin in our hospital and the clinical data reported in China were analyzed comprehensively. Results A total of 44 patients with acute renal failure caused by rifampicin in our hospital were included in this study. The general information, administration method, timing of occurrence, treatment and outcome of 44 patients were reported. Of the 32 patients who previously used rifampicin, 15 minutes to 50 days of onset, can be alleviated after active treatment. Conclusions In the process of using rifampicin, renal function should be closely monitored, and acute renal failure caused by rifampicin should be found in time.