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目的:探讨氯吡格雷与双嘧达莫联用对急性脑梗死患者血黏度的影响。方法:选取2015年12月—2016年5月间收治的新发急性脑梗死患者72例临床资料,采用随机分组法将其分为对照组33例和观察组39例;对照组患者给予口服氯吡格雷和阿司匹林肠溶片治疗,观察组患者给予口服氯吡格雷和双嘧达莫治疗,比较两组患者治疗后的总有效率,以及GMP140、血浆黏度、全血黏度和血小板聚集率等指标的变化情况。结果:两组患者治疗后的总有效率及GMP140、血浆黏度、全血黏度和血小板聚集率经组间比较其差异无统计学意义(P>0.05)。结论:采用氯吡格雷与双嘧达莫治疗急性脑梗死患者,其疗效果优于与阿司匹林肠溶片的治疗,但与双嘧达莫联用后可以减少不良反应的发生,可作为阿司匹林抵抗或过敏患者的替代药物。
Objective: To investigate the effect of clopidogrel combined with dipyridamole on blood viscosity in patients with acute cerebral infarction. Methods: A total of 72 patients with newly diagnosed acute cerebral infarction who were admitted between December 2015 and May 2016 were selected and randomly divided into control group (33 cases) and observation group (39 cases). Patients in the control group were given oral chlorine Patients in the observation group were treated with oral clopidogrel and dipyridamole. The total effective rate after treatment and the indexes of GMP140, plasma viscosity, whole blood viscosity and platelet aggregation were compared between the two groups. Changes in the situation. Results: The total effective rate and the GMP140, plasma viscosity, whole blood viscosity and platelet aggregation rate after treatment in both groups showed no significant difference after treatment (P> 0.05). Conclusion: Clopidogrel and dipyridamole in patients with acute cerebral infarction, the effect is better than with aspirin enteric-coated tablets, but with dipyridamole can reduce the incidence of adverse reactions, can be used as aspirin resistance Or allergic patients alternative medicine.