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目的研究新生儿败血症病原菌分布及药物敏感情况,以指导临床抗生素的使用。方法对我院53例败血症患儿感染菌株、药物敏感情况及相关临床资料进行回顾性分析,根据发生感染时间分为社区感染和医院感染。结果新生儿败血症社区感染多有典型症状和明确的感染史,主要病原菌为革兰阳性凝固酶阴性葡萄球菌,对青霉素、阿奇霉素耐药,对万古霉素敏感性好。医院感染则症状不典型,多数未发现明确感染灶,以革兰阴性肺炎克雷伯菌居多,对绝大部分青霉素类和头孢菌素类耐药,对碳青霉烯类敏感性好。结论重视抗生素的合理使用,根据药敏选用合适的药物,减少耐药菌株的产生。
Objective To study the distribution of neonatal sepsis pathogens and drug sensitivity to guide the use of clinical antibiotics. Methods 53 cases of sepsis in our hospital in children infected with drug-susceptibility and related clinical data were retrospectively analyzed, according to the time of infection is divided into community-based infections and nosocomial infections. Results Most of the neonatal sepsis patients had typical symptoms and clear infection history. The main pathogens were Gram-positive coagulase-negative staphylococci, resistant to penicillin and azithromycin and good to vancomycin. The symptoms of nosocomial infection is not typical, most did not find a clear focus of infection, Klebsiella pneumoniae mostly Klebsiella, most of the penicillins and cephalosporins resistance, good sensitivity to carbapenems. Conclusions The importance of rational use of antibiotics, selection of appropriate drugs based on drug susceptibility, reduce the generation of drug-resistant strains.