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自身免疫性血小板减少症(ATP)是由于血小板消除的增加而造成血液学疾患,患者体内产生了抗血小板抗体,导致致敏的血小板被网状内皮系统(RES)扣留。目前,主要治疗手段为皮质激素和脾切除术,其他治疗方法如单采血浆、γ-干扰素、免疫抑制剂等对ATP 也很有效。本文介绍的是用抗-D 治疗ATP。大量实验表明,IgG(IgG_1和IgG_3不包括IgG_2和IgG_4和活化的补体C_3)在免疫体外和体内介导的吞噬过程中起着重要作用。一旦IgG_1G_3或者C3b 粘附到细胞上,就会与RES 细胞上的特殊受体相结
Autoimmune thrombocytopenia (ATP), a haematological disorder caused by an increase in thrombocytopenia, produces anti-platelet antibodies in the body, causing sensitized platelets to be detained by the reticuloendothelial system (RES). Currently, the main treatment for corticosteroids and splenectomy, other treatments such as apheresis, interferon-γ, immunosuppressive agents, such as ATP is also very effective. This article describes the treatment of ATP with anti-D. Numerous experiments show that IgG (IgG 1 and IgG 3 excluding IgG 2 and IgG 4 and activated complement C 3) play an important role in the in vitro and in vivo mediated phagocytosis. Once IgG_1G_3 or C3b adheres to the cell, it binds to a specific receptor on the RES cell