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目的探讨血浆纤溶酶原激活物抑制剂-1基因启动子区4G/5G多态性与复发脑梗死之间的关系。方法应用PCR技术和琼脂糖电泳对58例初发脑梗死患者、64例复发脑梗死患者进行了API-1基因启动子4G/5G多态性的检测和分析,并与50例非脑血管疾病对照比较。结果两组脑梗死患者PAI-1基因启动子区4G/5G多态性的基因型频率和等位基因频率与对照组分别比较均有统计学差异(P<0.05),但复发脑梗死组患者PAI-1基因启动子区4G/5G多态性的基因型频率和等位基因频率与初发脑梗死组比较无统计学差异(P>0.05)。结论PAI-1基因启动子区4G/5G多态性是中国人群脑梗死发病的遗传学危险因素,但可能与复发脑梗死无关。
Objective To investigate the relationship between 4G / 5G polymorphism in plasminogen activator inhibitor-1 gene promoter region and recurrent cerebral infarction. Methods PCR-based agarose gel electrophoresis was used to detect and analyze the 4G / 5G polymorphism of API-1 promoter in 58 patients with primary cerebral infarction and 64 patients with recurrent cerebral infarction. The results were compared with 50 non-cerebrovascular diseases Comparison comparison. Results The frequencies of genotype and allele of 4G / 5G polymorphism in PAI-1 gene promoter region in both groups were significantly different from those in control group (P <0.05), but the patients with recurrent cerebral infarction The genotype frequency and allele frequency of 4G / 5G polymorphism in promoter region of PAI-1 gene were not significantly different from those in initial cerebral infarction group (P> 0.05). Conclusion 4G / 5G polymorphism of PAI-1 gene promoter region is a genetic risk factor for cerebral infarction in Chinese population, but it may not be related to recurrent cerebral infarction.