Effect of areca on contraction of colonic muscle strips in rats

来源 :World Journal of Gastroenterology | 被引量 : 0次 | 上传用户:sunuplee
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AIM:To investigate the effects of areca on the contractileactivity of isolated colonic muscle strips in rats andmechanism involved.METHODS:Each strip(LMPC,longitudinal muscle ofproximal colon;CMPC,circular muscle of proximal colon;LMDC,longitudinal muscle of distal colon;CMDC,circularmuscle of distal colon.)was suspended in a tissue chambercontaining 5 mL Krebs solution(37℃),bubbledcontinuously with 950 mL·L~(-1)O_2 and 50 mL·L~(-1)CO_2.Themean contractile amplitude(A),the resting tension(T),and the contractile frequency(F)were simultaneouslyrecorded on recorders.RESULTS:Areca dose dependently increased the meancontractile amplitude,the resting tension of proximal anddistal colonic smooth muscle strips in rats(P<0.05).Italso partly increased the contractile frequency of colonicsmooth muscle strips in rats(P<0.05).The effects werepartly inhibited by atropine(the resting tension of LMPCdecreased from 0.44±0.12 to 0.17±0.03;the restingtension of LMDC decreased from 0.71±0.14 to 0.03±0.01 ;the mean contractile amplitude of LMPC increased from-45.8±7.2 to-30.5±2.9;the motility index of CMDC decreasedfrom 86.6±17.3 to 32.8±9.3;P<0.05 vs areca),but theeffects were not inhibited by hexamethonium(P>0.05).CONCLUSION; Areca stimulated the motility of isolated colonic smooth muscle strips in rats. The stimulation of areca might be relevant with M receptor partly. AIM: To investigate the effects of areca on the contractileactivity of isolated colonic muscle strips in rats and mechanisms involved. METHODS: Each strip (LMPC, longitudinal muscle of male colon; CMPC, circular muscle of proximal colon; LMDC, longitudinal muscle of distal colon; CMDC , circularmuscle of distal colon.) was suspended in a tissue chamber containing 5 mL Krebs solution (bubbletcontinuously with 950 mL · L -1 O 2 and 50 mL·L -1 CO 2 .mean contractile amplitude ( A), the resting tension (T), and the contractile frequency (F) were simultaneouslyrecorded on recorders .RESULTS: Areca dose dependently increased the meancontractile amplitude, the resting tension of proximal anddistal colonic smooth muscle strips in rats (P <0.05). The effects were solely inhibited by atropine (the resting tension of LMP Canceled from 0.44 ± 0.12 to 0.17 ± 0.03; the resting extension of LMDC decreased from 0.71 ± 0.14 to 0.08 3 ± 0.01; the mean contractile amplitude of LMPC increased from -45.8 ± 7.2 to -30.5 ± 2.9; the motility index of CMDC decreased from 86.6 ± 17.3 to 32.8 ± 9.3; P <0.05 vs. areca), but the effects were not inhibited by hexamethonium (P> 0.05) .CONCLUSION; Areca stimulated the motility of isolated colonic smooth muscle strips in rats. The stimulation of areca might be relevant with M receptor partly.
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