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目的探讨抗结核药所致肝功能损害的临床治疗方法。方法将抗结核药物性肝损患者88例随机分为治疗组和对照组各44例:对照组给予门冬氨酸钾镁等治疗;治疗组予以甘草酸二胺加还原型谷胱甘肽治疗。2周后观察两组治疗前后患者的临床症状、体征和肝功能等变化情况。结果治疗组和对照组总有效率分别为95.5%和72.7%,治疗组疗效优于对照组,差异有显著性(P<0.05)。两组治疗前后肝功能明显改善,组间比较,差异有显著性(P<0.01)。治疗后治疗组的肝功能恢复情况明显优于对照组(P<0.05)。结论甘草酸二铵联合还原型谷胱甘肽治疗抗结核药物性肝损疗效确切,安全可靠。
Objective To investigate the clinical treatment of liver function damage caused by anti-TB drugs. Methods Eighty-eight patients with anti-tuberculosis drug-induced liver injury were randomly divided into treatment group (44 cases) and control group (44 cases). The control group was treated with potassium and magnesium aspartate, while the treatment group received glycyrrhizic acid diamine plus glutathione . Two weeks later, the changes of clinical symptoms, signs and liver function of the two groups before and after treatment were observed. Results The total effective rates in the treatment group and the control group were 95.5% and 72.7%, respectively. The curative effect in the treatment group was better than that in the control group (P <0.05). The liver function of the two groups improved significantly before and after treatment, the difference between the two groups was significant (P <0.01). After treatment, the liver function recovery of the treatment group was significantly better than that of the control group (P <0.05). Conclusion Glycyrrhizic acid diammonium combined with reduced glutathione in the treatment of anti-TB drug-induced liver injury is effective, safe and reliable.