制备了Cd_7Th,Zn_7Th,Pb_7Th,Hg_7Th,Bi_7Th等一系列金属硫蛋白(Thionein简称Th),研究了它们与配体反应的动力学,根据表观假一级反应速率常数,提出了不同配体与金属硫蛋白反应的两种机理,并且讨论了金属硫蛋白被Cd~(2+),Pb~(2+),Hg~(2+)等重金属离子在体内诱导的不同形成行为. A series of metallothioneins, such as Cd_7Th, Zn_7Th, Pb_7Th, Hg_7Th and Bi_7Th, were prepared and the kinetics of their reaction with ligands were studied. According to the apparent pseudo first order reaction rate constants, different ligands and Two mechanisms of metallothionein reaction were discussed, and the different formation behaviors of metallothionein in vivo induced by heavy metal ions such as Cd 2+, Pb 2+ and Hg 2+ were discussed.