论文部分内容阅读
目的:探讨早期肠内营养(EEN)联合双歧杆菌在急诊消化道穿孔病人中的应用效果。方法:将59例急诊消化道穿孔手术病人采用随机数字表法分为试验组(EN加双歧杆菌,n=31)和对照组(TPN,n=28)。试验组病人于术后第1天(<24 h)起给予EN支持;对照组于术后第1天开始行肠外营养(TPN)支持治疗。统计两组病人的平均住院时间、入住ICU时间、并发症发生率、炎性指标(血清C-反应蛋白)和营养学指标(前清蛋白、清蛋白)水平。结果:试验组病人平均住院时间,入住ICU时间、平均肠功能恢复时间和开始进食时间均较对照组明显缩短(P<0.05)。手术前后两组病人营养学指标无显著性差异(P>0.05)。术后第4天,试验组病人C-反应蛋白较对照组显著降低(P<0.05),术后切口感染裂开发生率较对照组显著降低(P<0.05),其余并发症发生率无显著性差异(P>0.05)。结论:早期给予EN联合双歧杆菌治疗,可明显缩短消化道穿孔病人术后肠功能恢复时间,缩短住院日,减少感染发生率,改善病人预后。
Objective: To investigate the effect of early enteral nutrition (EEN) combined with Bifidobacterium on emergency patients with gastrointestinal perforation. Methods: Fifty-nine patients with acute gastrointestinal perforation were randomly divided into test group (EN plus Bifidobacterium, n = 31) and control group (n = 28). Patients in the test group were given EN support on the first day after operation (<24 h). Patients in the control group received parenteral nutrition (TPN) support on the first day after operation. The average length of stay, ICU stay, complication rate, inflammatory markers (serum C-reactive protein) and nutritional indicators (prealbumin, albumin) were recorded. Results: The average length of hospital stay, ICU stay, mean intestine function recovery time and starting time of the patients in the experimental group were significantly shorter than those in the control group (P <0.05). There was no significant difference in nutritional indexes between the two groups before and after surgery (P> 0.05). On the fourth postoperative day, the C-reactive protein in the experimental group was significantly lower than that in the control group (P <0.05), and the incidence of incision infection was significantly lower than that in the control group (P <0.05), while the incidence of other complications was insignificant Sex differences (P> 0.05). Conclusions: Early treatment with EN combined with Bifidobacterium can shorten the recovery time of intestinal function, shorten the hospitalization days, reduce the incidence of infection and improve the prognosis of patients with gastrointestinal perforation.