目的：研究胃泌素释放肽前体、神经元特异性烯醇化酶、碳酸酐酶IX联合诊断对非小细胞肺癌的诊断价值。方法分析2012年6月-2013年6月我院收治的45例非小细胞癌患者的临床资料,选取52例在我院进行健康体检者作为对照组。分别检测两组研究对象血清中ProGRP、NSE、CAIX水平,分析其在外周血中的变化及临床意义。结果观察组研究对象血清中ProGRP、NSE、CAIX水平显著高于对照组,差异均具有统计学意义(P<0．05)；观察组Ⅲ期患者血清ProGRP、NSE、CAIX水平明显高于I+Ⅱ期患者,差异均具有统计学意义( P<0．05)；ROC曲线显示,当CAIX诊断分界点取值96．91 pg/mL时诊断敏感性为93．37%,特异性为92．31%,诊断价值均好于ProGRP、NSE,采用三种指标联合诊断发现,其诊断价值优于三者指标单独诊断；结论非小细胞肺癌患者外周血ProGRP、NSE、CAIX水平升高明显,与肿瘤分期正相关,联合诊断价值较高,可作为手术治疗效果新型评价指标。“,”Objective To investigate the diagnosis value for non-small cell lung cancer by combined Pro-GRP, NSE and CAIX. Methods The clinical data of 45 patients with non-small cell carcinoma in our hospital from June 2012 to June 2013 were analyzed, and they were enrolled as the observation group. 52 healthy cases were select-ed as the control group. Pro-GRP, NSE and CAIX were detected in both groups, and the changes and clinical signifi-cance in peripheral blood were analyzed. Results Pro-GRP in serum, NSE and CAIX in the observation group were significantly higher than those in the control group (P<0. 05). The levels of Pro-GRP, NSE and CAIX were obvi-ously higher in NSCLC patients at stage Ⅲ than in patients at stage I and Ⅱ ( P<0. 05 ) . ROC curve showed that when the cut-off point of CAIX was 96. 91 pg/mL, the diagnostic sensitivity was 93. 37%, the specificity was 92. 31%. The diagnostic value of CAIX was better than that of ProGRP and NSE. The diagnostic value of the three markers was better than the three indexes alone. Conclusion Peripheral blood Pro-GRP, NSE and CAIX elevate in non-small cell lung cancer patients, and they show positive correlation with tumor stage. The combined diagnosis has higher diagnostic value, and it can be used as the new evaluation index of the surgical treatment effect.