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目的:观察Hib疫苗与其他疫苗同时接种的临床反应。方法:选取2013年6月到2014年6月于我院进行疫苗接种的婴儿460例,随机分为对照组和观察组,每组230例,对照组中2个月大的婴儿接种OPV疫苗、4个月大的婴儿接种OPV+DTPa疫苗、6个月大的婴儿接种Hep B疫苗。观察组中2个月大的婴儿接种Hib+OPV疫苗,4个月大的婴儿接种Hib+OPV+DTPa疫苗,6个月大的婴儿接种Hib+Hep B疫苗,观察婴儿不同年龄接种疫苗后的不良反应。结果:观察组婴儿在不同年龄接种后的不良率分别为12.34%、13.65%、11.23%,而对照组不同年龄接种疫苗后的不良反应发生率分别为11.36%、13.96%、11.30%,两组对比具有统计学意义(P<0.05);治疗组的总满意度高于对照组,P<0.05,具有统计学意义。结论:在对婴儿进行疫苗接种时,采用Hib疫苗与其他疫苗同时接种,不会对婴儿造成明显的不良反应。
Objective: To observe the clinical response of simultaneous vaccination of Hib vaccine with other vaccines. Methods: A total of 460 infants vaccinated in our hospital from June 2013 to June 2014 were randomly divided into control group and observation group, with 230 cases in each group. The 2-month-old infants in control group were vaccinated with OPV, 4-month-old infants vaccinated with OPV + DTPa, 6-month-old infants vaccinated Hep B vaccine. The Hib + OPV vaccine was administered to 2-month-old infants in the observation group, Hib + OPV + DTPa vaccine was administered to 4-month-old infants, and Hib + Hep B vaccine was administered to infants of 6 months old. Different infants were vaccinated at different ages Adverse reactions. Results: The rates of adverse reactions in infants of observation group after inoculation at different ages were 12.34%, 13.65% and 11.23% respectively, while those in control group after vaccination were 11.36%, 13.96% and 11.30% (P <0.05). The total satisfaction of the treatment group was higher than that of the control group, P <0.05, with statistical significance. Conclusions: Simultaneous vaccination of infants with Hib vaccine with other vaccines results in no significant adverse effects on infants.