Wnt信号通路是体内重要的信号调节系统之一,而骨细胞作为骨组织中最主要的应力感受细胞,受载后可引起其内部Wnt信号通路的快速激活,最终调节其基因表达,影响骨改建。该激活过程受诸多调控因子的影响。本文就Wnt信号通路与骨细胞生物力刺激信号转导间的关系,以及该信号转导过程中Wnt信号通路的调控因子等研究进展作一综述。 Wnt signaling pathway is one of the most important signal regulation systems in the body. Osteoblasts, as the most important stress-sensing cells in bone tissue, can cause rapid activation of Wnt signaling pathway after being loaded and ultimately regulate its gene expression and affect bone remodeling . The activation process is influenced by many regulatory factors. This review summarizes the research progress of the relationship between Wnt signaling pathway and osteoblast biosensing signal transduction, and the regulatory factors of Wnt signaling pathway during the signal transduction.