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目的探讨血管内皮细胞生长因子(VEGF)和环氧化酶-2(COX-2)在血管瘤中的表达。方法收集2005—2007年中国医科大学盛京医院病理科皮肤血管瘤标本30例及同期的血管畸形标本26例(对照),采用免疫组化SABC法分别检测其中VEGF和COX-2的表达。结果 VEGF在血管瘤标本中均呈阳性表达,阳性率为100%,而在血管畸形标本中阳性率为46.15%,两组之间的差异有统计学意义(P<0.05)。COX-2在血管瘤标本中阳性率为93.33%,在血管畸形标本中的阳性率为42.30%,两组之间的差异有统计学意义(P<0.05)。结论 VEGF和COX-2在血管瘤血管内皮细胞上高表达,促进血管瘤增殖;在血管畸形的血管内皮细胞中低表达。其表达情况为临床治疗血管瘤提供了一种新思路。
Objective To investigate the expression of vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) in hemangiomas. Methods Thirty cases of pathological hemangiomas from Shengjing Hospital of China Medical University during 2005-2007 and 26 cases of vascular malformations were collected. The expressions of VEGF and COX-2 were detected by immunohistochemical SABC method. Results The positive rate of VEGF in hemangiomas was 100%, while the positive rate in vascular malformations was 46.15%. The difference between the two groups was statistically significant (P <0.05). The positive rate of COX-2 in hemangioma specimens was 93.33%, and the positive rate in vascular malformation specimens was 42.30%. The difference between the two groups was statistically significant (P <0.05). Conclusions VEGF and COX-2 are highly expressed on vascular endothelial cells of hemangiomas, which promote the proliferation of hemangiomas and low expression in vascular endothelial cells. Its expression provides a new idea for the clinical treatment of hemangiomas.