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支气管哮喘是一种以气道高反应性和慢性气道炎症为特征的变态反应性疾病。炎症细胞黏附到支气管内皮细胞是引起气道高反应性的关键步骤。细胞间黏附分子 1(I CAM 1)在炎症细胞的黏附、跨内皮转移并迁移至气道黏膜过程中起重要作用。ICAM 1基因至少有 2个多态性位点 ,这两个区
Bronchial asthma is an allergic disease characterized by airway hyperresponsiveness and chronic airway inflammation. Adhesion of inflammatory cells to bronchial endothelial cells is a key step in causing airway hyperresponsiveness. Intercellular adhesion molecule 1 (I CAM 1) plays an important role in the adhesion of inflammatory cells, transmetastasis and migration to airway mucosa. The ICAM 1 gene has at least two polymorphic sites in both regions