目的:观察雷莫司琼预防含顺铂化疗药物所致胃肠道反应的临床疗效和安全性。方法:采用随机自身对照方法,将入选80倒接受含顺铂联合化疗的恶性肿瘤患者,随机分成A、B两组,A、B两组病人于化疗第一周期分别使用甲氧氯普胺及格拉司琼作对照,第二周期均使用雷莫司琼止吐。结果:雷莫司琼预防化疗后呕吐明显优于甲氧氯普胺,其有效率分别为92.5%、42.5%。但雷莫司琼和格拉司琼预防化疗后呕吐无统计学差异,其有效率分别为90.0%、87.5%。结论:雷莫司琼能有效地预防含顺铂化疗药物所致胃肠道反应,与格拉司琼相似,但优于甲氧氯普胺。 Objective: To observe the clinical efficacy and safety of ramosetron in preventing gastrointestinal reactions caused by cisplatin-containing chemotherapy drugs. Methods: A randomized self-control method was used to divide 80 patients who received malignant tumor containing cisplatin combined with chemotherapy into A and B groups randomly. Patients in A and B groups were treated with metoclopramide and Granisetron as a control, the second cycle are used ramose Jones antiemetic. Results: Ramoxetine was superior to metoclopramide in preventing vomiting after chemotherapy. The effective rates were 92.5% and 42.5% respectively. However, there was no significant difference between ramosetron and granisetron in the prevention of vomiting after chemotherapy. The effective rates were 90.0% and 87.5% respectively. Conclusion: Ramosetron can effectively prevent gastrointestinal reactions caused by cisplatin-containing chemotherapy drugs, which is similar to granisetron but superior to metoclopramide.