遵义地区292例育龄期妇女多囊卵巢综合征临床分析

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目的:探讨遵义地区育龄期妇女多囊卵巢综合征(PCOS)患者的患病特征,为早期、科学合理诊治提供理论依据。方法:选取2007年11月~2009年9月遵义医学院附属医院就诊的育龄期妇女PCOS患者292例,同期因输卵管因素或者男方因素导致不孕就诊的育龄期妇女201例设为对照组。分析PCOS患者的一般症状、血清学特征、超声声像学特征及部分子宫内膜病理情况。结果:①遵义地区育龄期妇女PCOS患者常见临床征象依次为:超声显像示卵巢多囊性变(95.89%)、月经紊乱(89.38%)、不孕症(77.74%)、LH/FSH比值≥2(49.32%)、痤疮(36.99%)、肥胖(31.51%)、多毛(9.59%,F-G总分≥6分)。②多毛诊断标准以F-G总分≥2分作为临界值,本地PCOS患者多毛的发生率为30.82%。③PCOS患者LH、E2、T及LH/FSH水平均高于对照组,差异有统计学意义(P<0.01)。结论:①不同地区人群PCOS的临床表现和生化特征存在差异。对于遵义地区人群来说,月经不调和超声显像示卵巢多囊性变是育龄期妇女PCOS患者的主要临床特征。②LH/FSH≥2应作为筛查遵义地区PCOS患者的指标之一。③对于多毛的诊断标准,F-G总分≥2分可能更适合于遵义地区人群。 Objective: To investigate the prevalence of polycystic ovary syndrome (PCOS) in women of childbearing age in Zunyi and to provide a theoretical basis for early diagnosis and treatment. Methods: A total of 292 women of childbearing age were selected from November 2007 to September 2009 in Zunyi Medical College Affiliated Hospital. 201 women of childbearing age who were infertile due to fallopian tube or male factors were selected as the control group. To analyze the general symptoms, serological features, ultrasonographic characteristics and some endometrial pathology in patients with PCOS. Results: ①The common clinical signs of PCOS in women of childbearing age in Zunyi were as follows: ultrasound showed multiple polycystic ovarian changes (95.89%), menstrual disorders (89.38%), infertility (77.74%), LH / FSH ratio≥ Acne (36.99%), obesity (31.51%), hirsutism (9.59%, FG score> = 6 points). ② The diagnostic criteria for hairy hair with F-G score ≥ 2 points as a critical value, the incidence of local PCOS hirsutism was 30.82%. ③ The levels of LH, E2, T and LH / FSH in PCOS patients were significantly higher than those in control group (P <0.01). Conclusion: ① There are differences in the clinical features and biochemical characteristics of PCOS in different areas. For the population of Zunyi, irregular menstruation and ultrasound imaging of ovarian polycystic ovary is the main clinical features of women of childbearing age PCOS. ②LH / FSH≥2 should be used as one of the indicators screening PCOS patients in Zunyi area. ③ For the diagnosis of hirsutism, F-G total score ≥ 2 points may be more suitable for people in Zunyi region.
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