为探索新的农药先导化合物,经取代苯基呋喃甲酰氯与5-肼基-3(2H)哒嗪酮反应,得到15个未见文献报道的含呋喃环3(2H)哒嗪酮类化合物,其结构均通过了红外光谱、核磁共振氢谱和元素分析确认。初步生物活性测定结果表明,目标化合物具有良好的杀菌活性,但杀虫活性较弱。其中化合物3k在50 mg/L时对灰霉病菌的抑制率为86.29%±1.51%,与对照药剂腐霉利相当。初步的构效关系研究结果显示,苯环上取代基的种类和位置对杀菌活性有重要影响。 In order to explore a new pesticide lead compound, 15 new pyridazinones containing furan ring 3 (2H) were obtained by reaction of substituted phenyl furoyl chloride with 5-hydrazinyl-3 (2H) pyridazinone The structures were confirmed by IR, 1H NMR and elemental analysis. The preliminary bioassay results showed that the target compounds had good bactericidal activity but insecticidal activity. The inhibitory rate of compound 3k against Botrytis cinerea at 50 mg / L was 86.29% ± 1.51%, which was comparable to that of the control agent. Preliminary structure-activity relationship results show that the types and positions of substituents on the benzene ring have a significant impact on the bactericidal activity.