糖尿病肾病(diabetic nephropathy,DN)是糖尿病最常见的并发症之一。以往对DN的研究大多数着眼于其肾小球的病变,诸如肾小球通透性和毛细血管壁的异常,肾小球的肥大或(和)增生,基底膜增厚,以及系膜区体积增大等发病机理的研究。尽管已有文献报道,糖尿病的肾小管功能和结构也有明显变化。但是,此时肾小管-间质损伤在DN发生和进展中的作用,却很少引起人们的重视。因此,全面地了解导致DN肾功能不可逆丧失 Diabetic nephropathy (DN) is one of the most common complications of diabetes. Previous studies of DN mostly focused on the glomerular lesions such as glomerular permeability and capillary wall abnormalities, glomerular hypertrophy or hyperplasia, thickening of the basement membrane, and mesangial area Volume increase and other pathogenesis research. Although it has been reported in the literature, there is a significant change in the function and structure of renal tubules in diabetes. However, at this time, the role of tubulointerstitial injury in the occurrence and progression of DN has seldom aroused people’s attention. Therefore, a comprehensive understanding of the irreversible loss of renal function leading to DN