目的　研究153 Sm -EDTMP治疗肺癌、乳癌及前列腺癌骨转移所致骨痛的疗效。方法　静脉注射153 Sm -EDTMP ,给药剂量 18 5～ 3 7MBq/kg( 0 5～ 1 0mCi/kg)体重 ,每隔 1～ 2个月 1次注射。结果　肺癌、乳癌及前列腺癌153 Sm -EDTMP治疗骨痛的总有效率分别为 68 5 %、89 3 %及 10 0 % ,且乳癌和前列腺癌的疗效与肺癌相比有明显差异 (P <0 0 0 5 ) ,多数患者 ( 81 5 % )WBC或PLT一过性减少。结论　放射性核素治疗以成骨为主的骨转移灶 ,止痛效果明显 ,方法简便 ,副作用小 Objective To investigate the therapeutic effect of 153 Sm-EDTMP on bone pain caused by bone metastasis of lung cancer, breast cancer and prostate cancer. Methods 153 Sm -EDTMP was intravenously injected at a dose of 18 5 ~ 37 MBq / kg (0 5 ~ 10 mCi / kg) and injected once every 1 ~ 2 months. Results The total effective rates of 153 Sm-EDTMP in treating lung cancer, breast cancer and prostate cancer were 68 5%, 89 3% and 100%, respectively. The efficacy of breast cancer and prostate cancer was significantly different from that of lung cancer (P <0 0 0 5), the majority of patients (81 5%) had a transient decrease in WBC or PLT. Conclusion Radionuclide therapy is mainly osteogenic bone metastases, the analgesic effect is obvious, the method is simple and the side effects are small