哺乳动物造血系统,在正常稳态下,大多数干细胞和早期造血祖细胞处于非增殖状态。当机体需要增加造血时,这些非增殖态细胞可迅速表现出很强的增殖活性。一般可通过两条途径:在正常情况下处于基础状态的细胞受到正调控信号(刺激信号)刺激后,活化进入增殖态;或只要正调控信号与负调控信号(抑制信号)处于平衡状态,这些细胞就可维持动 Mammalian hematopoietic system, in normal homeostasis, most stem cells and early hematopoietic progenitor cells are in a nonproliferative state. When the body needs to increase hematopoiesis, these non-proliferating cells can rapidly exhibit strong proliferative activity. Generally, there are two ways: under normal conditions, the cells in the basal state are activated and enter the proliferative state after being stimulated by positive regulatory signals (stimulation signals); or as long as the positive regulatory signals and the negative regulatory signals (inhibitory signals) are in balance, Cells can be maintained