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目的:观察龙鳖胶囊治疗膝骨关节炎的临床疗效及其对膝骨关节炎患者生活质量的影响。方法:将符合纳入标准的88例患者,随机分为龙鳖胶囊组44例和塞来昔布组44例,分别给予口服龙鳖胶囊和塞来昔布,两组均以4周为观察期,对两组患者治疗后的临床疗效、VAS评分、Lequesne指数、胃肠道不良反应、关节炎影响测定量表评分进行评价。结果:龙鳖胶囊组总有效率92.25%,塞来昔布组总有效率90.00%,两组总有效率无显著性差异(P>0.05)。与治疗前比较,龙鳖胶囊组和塞来昔布组的VAS评分、Lequesne指数、关节炎影响测定量表评分均较前明显改善,具有显著性差异(P<0.01)。治疗期间,龙鳖胶囊组出现胃肠道反应4例,塞来昔布组出现胃肠道反应3例,两组不良反应发生率比较,无显著性差异(P>0.05)。治疗后组间比较,龙鳖胶囊组和塞来昔布组在VAS评分、Lequesne指数方面无显著性差异(P>0.05);龙鳖胶囊组的关节炎影响测定量表评分低于塞来昔布组,具有显著性差异(P<0.01)。结论:采用龙鳖胶囊和塞来昔布治疗膝骨关节炎,均可有效缓解症状、改善膝关节功能,具有良好的有效性和安全性;但龙鳖胶囊在改善生活质量方面优于塞来昔布。
Objective: To observe the clinical efficacy of Long Tu Capsule in treating knee osteoarthritis and its effect on quality of life in patients with knee osteoarthritis. Methods: A total of 88 patients who met the inclusion criteria were randomly divided into two groups: 44 cases in Longtie capsule group and 44 cases in Celecoxib group. The rabbits were given oral Longyibai capsule and celecoxib respectively. Both groups were given 4 weeks observation period The clinical efficacy, VAS score, Lequesne index, adverse gastrointestinal tract, and arthritis impact scale were evaluated in two groups after treatment. Results: The total effective rate of Long turtle capsule group was 92.25%, and the total effective rate of celecoxib group was 90.00%. There was no significant difference between the two groups (P> 0.05). Compared with those before treatment, VAS score, Lequesne index and arthritis influence scale of Longyou capsule group and celecoxib group were significantly improved compared with those before treatment (P <0.01). During treatment, there were 4 gastrointestinal reactions in Longyou capsule group and 3 gastrointestinal reactions in Celecoxib group. There was no significant difference between the two groups in the incidence of adverse reactions (P> 0.05). After treatment, there was no significant difference in VAS score and Lequesne index between Longteng capsule group and celecoxib group (P> 0.05). The score of arthritis influence scale of Longteng capsule group was lower than that of Celecoxib Cloth group, with significant differences (P <0.01). Conclusion: Long turtle capsules and celecoxib treatment of knee osteoarthritis, can effectively relieve symptoms and improve knee function, with good effectiveness and safety; but Long Turtle capsule in improving the quality of life than the Cypriot Cocoon