人免疫缺陷病毒(HIV-1)调节蛋白Rev是病毒复制中调节非拼接转录本出核转运所必需的。Rev核功能需要活跃的核质穿梭,Rev核输入由它的核定位信号介导,并受多种因素影响,其中包括转运蛋白和输入蛋白B。爱尔兰科学家的研究工作确认细胞蛋白HIC(human Ⅰ-mfa domain-containing protein)能与HIV-1 Rev蛋白相互作用。HIC选择性干扰Rev在核定位 Human immunodeficiency virus (HIV-1) regulatory protein Rev is required for the regulation of non-spliced ​​transcripts for nuclear transport in viral replication. The Rev nuclear function requires an active nuclear transport. The Rev nuclear input is mediated by its nuclear localization signal and is affected by several factors, including transporter and input protein B. Irish scientists confirmed that the cellular protein HIC (human I-mfa domain-containing protein) can interact with HIV-1 Rev protein. HIC selectively disrupts Rev in nuclear localization