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目的:研究辛伐他汀对鼻咽癌细胞株CNE2细胞迁移的作用.方法:用损伤修复实验和tran-swell实验观察辛伐他汀对鼻咽癌细胞株CNE2细胞迁移的抑制作用.结果:损伤修复实验结果显示,辛伐他汀浓度和时间依赖性地抑制鼻咽癌细胞株CNE2细胞迁移,2.5 μmol/L的辛伐他汀作用24 h,其迁移距离为对照组24 h的50.1%.tran-swell实验结果表明2.5μmol/L的辛伐他汀处理24 h,迁移细胞数量为对照组的69.2%.结论:辛伐他汀能浓度、时间依赖性地抑制CNE2细胞迁移.为辛伐他汀的临床研究提供有利的线索.“,”AIM: To study the effect of simvastatin on cells migration of nasophaiyngeal carcinoma cell line CNE2 in vitro . METHODS: The depressive effects of simvastatin on CNE2 cells migration were observed by scratch wound healing assay and transwell migration assay. RESULTS: The experimental result of scratch wound healing assay showed that simvastatin inhibited migration of nasopharyngeal carcinoma CNE2 cells in a time-and dose-dependent manner. With 2.5 μmol/L simvastatin treatment for 24 hs, the migration lenth was 50.1 % of that in control group. Transwell experimental result indicated that with 2.5 μmol/L simvastatin treatment for 24 hs, the migrating cell population was 69.2% of that in control group. CONCLUSION: Simvastatin can inhibits CNE2 cells migration in a time-and dose-dependent manner, which can provide rational clues for clinical research of simvastatin.