survivin及其剪切异构体参与了控制细胞分裂和抑制细胞凋亡。它在正常成人组织不表达,在多种肿瘤组织中高表达,使其成为肿瘤标志物和抗癌治疗中一项具有吸引力的研究目标。近年,survivin亚细胞定位与肿瘤的关系成了研究热点,现就survivin及其剪切异构体的亚细胞定位及其与卵巢癌关系的研究进展作一综述。 Survivin and its cleavage isoforms are involved in controlling cell division and inhibiting apoptosis. It is not expressed in normal adult tissues and highly expressed in a variety of tumor tissues, making it an attractive research target for tumor markers and anticancer therapies. In recent years, the relationship between survivin subcellular localization and tumor has become a hot research topic. The research progress on the subcellular localization of survivin and its splice isoforms and its relationship with ovarian cancer is reviewed.