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目前热带病学最主要的问题之一是氯喹抗药性的日益广泛,至今氯喹还是最可靠的防治疟疾的药物。过去3年镰状疟原虫对氯喹与砜类药物并用,或者与磺胺加有乙胺嘧啶并用已出现抗药性,这意味着对现存的合成抗疟药中没有一个可以信赖。甲氟喹是一种有价值的新合成化合物,美军研究组曾试验过,但是由于在等待战场试验
At present, one of the most important problems in tropical medicine is the increasingly wide range of chloroquine resistance. Chloroquine is still the most reliable drug against malaria so far. Plasmodium falciparum has been shown to be resistant to chloroquine and sulfone over the past three years or to pyrimethamine plus pyrimethamine, meaning that none of the existing synthetic antimalarials can be trusted. Mefloquine is a valuable new synthetic compound that the U.S. Army’s research team had tested but which, while awaiting battlefield trials