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目的:医院传统经验方剂复方紫柄冬青软膏的再评价。方法:回顾性分析该软膏的起源及临床应用范围;对处方药材进行生药学鉴定;以金黄色葡萄球菌、大肠埃希菌、铜绿假单胞菌等3种致病菌株为实验菌株,对软膏进行体外抗菌作用考察。结果:生药学鉴定紫柄冬青为冬青科冬青属植物四季青(Ilex chinensis folium);银花为忍冬科山银花(Lonicerae flos);含药0.015 62,0.062 5和0.125 g·mL-1复方紫柄冬青软膏样品溶液分别对大肠埃希菌;铜绿假单胞菌和大肠埃希菌;金黄色葡萄球菌、铜绿假单胞菌及大肠埃希菌有抑制作用。结论:体外抗菌考察结果从现代药理学角度,解释了此传统医院经验方剂用于烧伤、烫伤、感染性伤口及促进溃疡面愈合等具有一定临床疗效的结论。
OBJECTIVE: Revaluation of traditional prescription prescription hospital compound purple handle hollyhock ointment. Methods: The origin and clinical application of the ointment were retrospectively analyzed. Pharmacognosy was performed on the prescription herbs. Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were selected as experimental strains. Antibacterial activity in vitro study. Results: The pharmacognosy identification of Hollyhock Hollyhock was the Ilex chinensis folium, the honeysuckle was Lonicerae flos, the contents of 0.015 62, 0.062 5 and 0.125 g · mL -1 Hollyhysia orientalis ointment sample solution respectively against Escherichia coli; Pseudomonas aeruginosa and Escherichia coli; Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli inhibitory effect. Conclusion: In vitro antibacterial investigation results from the perspective of modern pharmacology, explains the traditional hospital experience prescription for burn, scald, infectious wounds and promote ulcer healing has some clinical efficacy conclusion.